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Sue Clark (Editor)
Intensive research over the last fifteen years has yielded a vast expansion in
our understanding of the role of inheritance and genetics in a variety of
cancers. Several inherited conditions have been identified which result in a
high risk of various cancers; some of these were previously recognised, but the
genetic basis underlying them has now been elucidated. This knowledge is now
entering the sphere of routine clinical care. Once the preserve of researchers
and highly specialised units, genetic testing for cancer predisposition is now
accessible to most clinicians via regional genetics units; in the USA patients
can access commercial genetic testing facilities. There is a growing evidence
base to guide family screening and clinical management of affected
individuals.Surgeons, gastroenterologists, gynaecologists, oncologists,
endocrinologists and many others need an awareness of these disorders, an
understanding of genetic testing and when it is indicated, and how to manage
patients with inherited cancer predisposition and their families. Testing for
these conditions has potential legal, ethical and financial implications
different from those which most clinicians regularly encounter, and continuing
scientific and clinical advance means that patients and their doctors will face
regular changes in management. This book covers the basic concepts of cancer
genetics. The common inherited cancer syndromes are each dealt with in greater
depth, with the current management outlined.This book is aimed at all clinicians
who may encounter these conditions in their practice. It aims to facilitate
identification of high-risk individuals and families, to inform interaction with
geneticists and other sub-specialists, to provide a basis for patient management
and to stimulate interest in these fascinating conditions. |
